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Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding
The Cdc48 ATPase (p97 or VCP in mammals) and its cofactor Ufd1/Npl4 extract poly-ubiquitinated proteins from membranes or macromolecular complexes for subsequent degradation by the proteasome. How Cdc48 processes its diverse and often well-folded substrates is unclear. Here, we report cryo-EM struct...
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| Publicado no: | Science |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6980381/ https://ncbi.nlm.nih.gov/pubmed/31249135 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aax1033 |
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