Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding

The Cdc48 ATPase (p97 or VCP in mammals) and its cofactor Ufd1/Npl4 extract poly-ubiquitinated proteins from membranes or macromolecular complexes for subsequent degradation by the proteasome. How Cdc48 processes its diverse and often well-folded substrates is unclear. Here, we report cryo-EM struct...

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Gepubliceerd in:Science
Hoofdauteurs: Twomey, Edward C., Ji, Zhejian, Wales, Thomas E., Bodnar, Nicholas O., Ficarro, Scott B., Marto, Jarrod A., Engen, John R., Rapoport, Tom A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980381/
https://ncbi.nlm.nih.gov/pubmed/31249135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aax1033
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