Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding

The Cdc48 ATPase (p97 or VCP in mammals) and its cofactor Ufd1/Npl4 extract poly-ubiquitinated proteins from membranes or macromolecular complexes for subsequent degradation by the proteasome. How Cdc48 processes its diverse and often well-folded substrates is unclear. Here, we report cryo-EM struct...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Science
Autori principali: Twomey, Edward C., Ji, Zhejian, Wales, Thomas E., Bodnar, Nicholas O., Ficarro, Scott B., Marto, Jarrod A., Engen, John R., Rapoport, Tom A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980381/
https://ncbi.nlm.nih.gov/pubmed/31249135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aax1033
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi