Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1-Npl4

Many poly-ubiquitinated proteins are extracted from membranes or complexes by a conserved ATPase, called Cdc48 in yeast and p97/VCP in mammals, before proteasomal degradation(1). Each Cdc48 hexamer contains two stacked ATPase rings (D1 and D2) and six N-terminal (N) domains(2). Cdc48 binds various c...

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Udgivet i:Nat Struct Mol Biol
Main Authors: Bodnar, Nicholas O., Kim, Kelly H., Ji, Zhejian, Wales, Thomas E., Svetlov, Vladimir, Nudler, Evgeny, Engen, John R., Walz, Thomas, Rapoport, Tom A.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6044470/
https://ncbi.nlm.nih.gov/pubmed/29967539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-018-0085-x
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