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Role of the ubiquitin-selective CDC48(UFD1/NPL4) chaperone (segregase) in ERAD of OLE1 and other substrates

The OLE pathway of yeast regulates the abundance of the ER-bound enzyme Δ-9 fatty acid desaturase OLE1, thereby controlling unsaturated fatty acid pools and membrane fluidity. Previously, we showed that this pathway is exquisitely regulated by the ubiquitin/proteasome system. Activation of the pathw...

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Détails bibliographiques
Auteurs principaux: Braun, Sigurd, Matuschewski, Kai, Rape, Michael, Thoms, Sven, Jentsch, Stefan
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2002
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC125867/
https://ncbi.nlm.nih.gov/pubmed/11847109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/21.4.615
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