Dual Recruitment of Cdc48 (p97)-Ufd1-Npl4 Ubiquitin-selective Segregase by Small Ubiquitin-like Modifier Protein (SUMO) and Ubiquitin in SUMO-targeted Ubiquitin Ligase-mediated Genome Stability Functions

Protein modification by SUMO and ubiquitin critically impacts genome stability via effectors that “read” their signals using SUMO interaction motifs or ubiquitin binding domains, respectively. A novel mixed SUMO and ubiquitin signal is generated by the SUMO-targeted ubiquitin ligase (STUbL), which u...

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Main Authors: Nie, Minghua, Aslanian, Aaron, Prudden, John, Heideker, Johanna, Vashisht, Ajay A., Wohlschlegel, James A., Yates, John R., Boddy, Michael N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436128/
https://ncbi.nlm.nih.gov/pubmed/22730331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.379768
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