p53 Mediates Vast Gene Expression Changes That Contribute to Poor Chemotherapeutic Response in a Mouse Model of Breast Cancer()()

p53 is a transcription factor that regulates expression of genes involved in cell cycle arrest, senescence, and apoptosis. TP53 harbors mutations that inactivate its transcriptional activity in roughly 30% of breast cancers, and these tumors are much more likely to undergo a pathological complete re...

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Bibliographische Detailangaben
Veröffentlicht in:Transl Oncol
Hauptverfasser: Tonnessen-Murray, Crystal, Ungerleider, Nathan A., Rao, Sonia G., Wasylishen, Amanda R., Frey, Wesley D., Jackson, James G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Neoplasia Press 2018
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Original article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6041561/
https://ncbi.nlm.nih.gov/pubmed/29852458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2018.05.003
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