BH3 mimetics selectively eliminate chemotherapy-induced senescent cells and improve response in TP53 wild-type breast cancer

TP53 wild-type breast tumors rarely undergo a complete pathological response after chemotherapy treatment. These patients have an extremely poor survival rate and studies show these tumors preferentially undergo senescence instead of apoptosis. These senescent cells persist after chemotherapy and se...

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Bibliographic Details
Published in:Cell Death Differ
Main Authors: Shahbandi, Ashkan, Rao, Sonia G., Anderson, Ashlyn Y., Frey, Wesley D., Olayiwola, Joy O., Ungerleider, Nathan A., Jackson, James G.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7560696/
https://ncbi.nlm.nih.gov/pubmed/32457483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-0564-6
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