BH3 mimetics selectively eliminate chemotherapy-induced senescent cells and improve response in TP53 wild-type breast cancer

TP53 wild-type breast tumors rarely undergo a complete pathological response after chemotherapy treatment. These patients have an extremely poor survival rate and studies show these tumors preferentially undergo senescence instead of apoptosis. These senescent cells persist after chemotherapy and se...

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Publicado en:Cell Death Differ
Autores principales: Shahbandi, Ashkan, Rao, Sonia G., Anderson, Ashlyn Y., Frey, Wesley D., Olayiwola, Joy O., Ungerleider, Nathan A., Jackson, James G.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7560696/
https://ncbi.nlm.nih.gov/pubmed/32457483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-0564-6
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