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Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias
Selective targeting of BCL-2 with the BH3-mimetic venetoclax has been a transformative treatment for patients with various leukemias. TP-53 controls apoptosis upstream of where BCL-2 and its prosurvival relatives, such as MCL-1, act. Therefore, targeting these prosurvival proteins could trigger apop...
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| Udgivet i: | Blood |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society of Hematology
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8138548/ https://ncbi.nlm.nih.gov/pubmed/33824975 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020010167 |
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