Oxygen drives hepatocyte differentiation and phenotype stability in liver cell lines

The in vitro generation of terminally differentiated hepatocytes is an unmet need. We investigated the contribution of oxygen concentration to differentiation in human liver cell lines HepaRG and C3A. HepaRG cells were cultured under hypoxia (5%O(2)), normoxia (21%O(2)) or hyperoxia (40%O(2)). Cultu...

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Bibliografiska uppgifter
I publikationen:J Cell Commun Signal
Huvudupphovsmän: van Wenum, Martien, Adam, Aziza A. A., van der Mark, Vincent A., Chang, Jung-Chin, Wildenberg, Manon E., Hendriks, Erik J., Jongejan, Aldo, Moerland, Perry D., van Gulik, Thomas M., Oude Elferink, Ronald P., Chamuleau, Robert A. F. M., Hoekstra, Ruurdtje
Materialtyp: Artigo
Språk:Inglês
Publicerad: Springer Netherlands 2018
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6039343/
https://ncbi.nlm.nih.gov/pubmed/29399736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12079-018-0456-4
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