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Oxygen drives hepatocyte differentiation and phenotype stability in liver cell lines

The in vitro generation of terminally differentiated hepatocytes is an unmet need. We investigated the contribution of oxygen concentration to differentiation in human liver cell lines HepaRG and C3A. HepaRG cells were cultured under hypoxia (5%O(2)), normoxia (21%O(2)) or hyperoxia (40%O(2)). Cultu...

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Bibliografische gegevens
Gepubliceerd in:J Cell Commun Signal
Hoofdauteurs: van Wenum, Martien, Adam, Aziza A. A., van der Mark, Vincent A., Chang, Jung-Chin, Wildenberg, Manon E., Hendriks, Erik J., Jongejan, Aldo, Moerland, Perry D., van Gulik, Thomas M., Oude Elferink, Ronald P., Chamuleau, Robert A. F. M., Hoekstra, Ruurdtje
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer Netherlands 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6039343/
https://ncbi.nlm.nih.gov/pubmed/29399736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12079-018-0456-4
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