Oxygen drives hepatocyte differentiation and phenotype stability in liver cell lines

The in vitro generation of terminally differentiated hepatocytes is an unmet need. We investigated the contribution of oxygen concentration to differentiation in human liver cell lines HepaRG and C3A. HepaRG cells were cultured under hypoxia (5%O(2)), normoxia (21%O(2)) or hyperoxia (40%O(2)). Cultu...

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Dettagli Bibliografici
Pubblicato in:J Cell Commun Signal
Autori principali: van Wenum, Martien, Adam, Aziza A. A., van der Mark, Vincent A., Chang, Jung-Chin, Wildenberg, Manon E., Hendriks, Erik J., Jongejan, Aldo, Moerland, Perry D., van Gulik, Thomas M., Oude Elferink, Ronald P., Chamuleau, Robert A. F. M., Hoekstra, Ruurdtje
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Netherlands 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6039343/
https://ncbi.nlm.nih.gov/pubmed/29399736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12079-018-0456-4
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