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Oxygen drives hepatocyte differentiation and phenotype stability in liver cell lines
The in vitro generation of terminally differentiated hepatocytes is an unmet need. We investigated the contribution of oxygen concentration to differentiation in human liver cell lines HepaRG and C3A. HepaRG cells were cultured under hypoxia (5%O(2)), normoxia (21%O(2)) or hyperoxia (40%O(2)). Cultu...
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| Veröffentlicht in: | J Cell Commun Signal |
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| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Springer Netherlands
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6039343/ https://ncbi.nlm.nih.gov/pubmed/29399736 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12079-018-0456-4 |
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