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Oxygen drives hepatocyte differentiation and phenotype stability in liver cell lines

The in vitro generation of terminally differentiated hepatocytes is an unmet need. We investigated the contribution of oxygen concentration to differentiation in human liver cell lines HepaRG and C3A. HepaRG cells were cultured under hypoxia (5%O(2)), normoxia (21%O(2)) or hyperoxia (40%O(2)). Cultu...

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Detaylı Bibliyografya
Yayımlandı:J Cell Commun Signal
Asıl Yazarlar: van Wenum, Martien, Adam, Aziza A. A., van der Mark, Vincent A., Chang, Jung-Chin, Wildenberg, Manon E., Hendriks, Erik J., Jongejan, Aldo, Moerland, Perry D., van Gulik, Thomas M., Oude Elferink, Ronald P., Chamuleau, Robert A. F. M., Hoekstra, Ruurdtje
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Springer Netherlands 2018
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6039343/
https://ncbi.nlm.nih.gov/pubmed/29399736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12079-018-0456-4
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