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Improved oxygenation dramatically alters metabolism and gene expression in cultured primary mouse hepatocytes

Primary hepatocyte culture is an important in vitro system for the study of liver functions. In vivo, hepatocytes have high oxidative metabolism. However, oxygen supply by means of diffusion in in vitro static cultures is much less than that by blood circulation in vivo. Therefore, we investigated w...

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Detalhes bibliográficos
Publicado no:Hepatol Commun
Main Authors: Gilglioni, Eduardo H., Chang, Jung‐Chin, Duijst, Suzanne, Go, Simei, Adam, Aziza A. A., Hoekstra, Ruurdtje, Verhoeven, Arthur J., Ishii‐Iwamoto, Emy L., Oude Elferink, Ronald P.J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5831026/
https://ncbi.nlm.nih.gov/pubmed/29507904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep4.1140
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