Fatty Acid Amide Hydrolase Inhibition by JNJ‐42165279: A Multiple‐Ascending Dose and a Positron Emission Tomography Study in Healthy Volunteers

Inhibition of fatty acid amide hydrolase (FAAH) potentiates endocannabinoid activity and is hypothesized to have therapeutic potential for mood and anxiety disorders and pain. The clinical profile of JNJ‐42165279, an oral selective FAAH inhibitor, was assessed by investigating the pharmacokinetics,...

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發表在:Clin Transl Sci
Main Authors: Postnov, Andrey, Schmidt, Mark E., Pemberton, Darrel J., de Hoon, Jan, van Hecken, Anne, van den Boer, Maarten, Zannikos, Peter, van der Ark, Peter, Palmer, James A., Rassnick, Stef, Celen, Sofie, Bormans, Guy, van Laere, Koen
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2018
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6039207/
https://ncbi.nlm.nih.gov/pubmed/29575526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12548
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