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Rewiring T-cell responses to soluble factors with chimeric antigen receptors
Chimeric antigen receptor (CAR)-expressing T cells targeting surface-bound tumor antigens have yielded promising clinical outcomes, with two CD19 CAR-T cell therapies recently receiving FDA approval for the treatment of B-cell malignancies. The adoption of CARs for the recognition of soluble ligands...
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| Publicado en: | Nat Chem Biol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6035732/ https://ncbi.nlm.nih.gov/pubmed/29377003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2565 |
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