Increased sensitivity to apoptosis upon endoplasmic reticulum stress-induced activation of the unfolded protein response in chemotherapy-resistant malignant pleural mesothelioma

BACKGROUND: Standard treatment for advanced malignant pleural mesothelioma (MPM) is a cisplatin/pemetrexed (MTA) regimen; however, this is confronted by drug resistance. Proteotoxic stress in the endoplasmic reticulum (ER) is a hallmark of cancer and some rely on this stress signalling in response t...

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Pubblicato in:Br J Cancer
Autori principali: Xu, Duo, Liang, Shun-Qing, Yang, Haitang, Lüthi, Ursina, Riether, Carsten, Berezowska, Sabina, Marti, Thomas M., Hall, Sean R. R., Bruggmann, Rémy, Kocher, Gregor J., Schmid, Ralph A., Peng, Ren-Wang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6035279/
https://ncbi.nlm.nih.gov/pubmed/29921948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-018-0145-3
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