Malignant pleural mesothelioma co-opts BCL-X(L) and autophagy to escape apoptosis

Escape from programmed cell death is a hallmark of cancer. In this study, we investigated the anti-apoptotic mechanisms and explored the therapeutic potential of BCL-2 homology domain-3 (BH3) mimetics in malignant pleural mesothelioma (MPM), a lethal thoracic malignancy with an extreme dearth of tre...

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Bibliographic Details
Published in:Cell Death Dis
Main Authors: Xu, Duo, Liang, Shun-Qing, Yang, Zhang, Yang, Haitang, Bruggmann, Rémy, Oberhaensli, Simone, Berezowska, Sabina, Marti, Thomas M., Hall, Sean R. R., Dorn, Patrick, Kocher, Gregor J., Schmid, Ralph A., Peng, Ren-Wang
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8050302/
https://ncbi.nlm.nih.gov/pubmed/33859162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03668-x
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