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ΔNp73 enhances HIF-1α protein stability through repression of the ECV complex
Cellular responses to low oxygen conditions are mainly regulated by the Hypoxia-inducible factors (HIFs). Induction of HIF-1α in tumor cells activates the angiogenic switch and allows for metabolic adaptations. HIF-1α protein levels are tightly regulated through ubiquitin-mediated proteosomal degrad...
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| Publicado no: | Oncogene |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6033838/ https://ncbi.nlm.nih.gov/pubmed/29628507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0195-2 |
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