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ΔNp73 enhances HIF-1α protein stability through repression of the ECV complex

Cellular responses to low oxygen conditions are mainly regulated by the Hypoxia-inducible factors (HIFs). Induction of HIF-1α in tumor cells activates the angiogenic switch and allows for metabolic adaptations. HIF-1α protein levels are tightly regulated through ubiquitin-mediated proteosomal degrad...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Oncogene
Päätekijät: Stantic, Marina, Wolfsberger, Johanna, Sakil, Habib A. M., Wilhelm, Margareta T.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2018
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6033838/
https://ncbi.nlm.nih.gov/pubmed/29628507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0195-2
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