Inhibition of NF-κB signaling in IKKβ(F/F);LysM Cre mice causes motor deficits but does not alter pathogenesis of Spinocerebellar ataxia type 1

Spinocerebellar Ataxia type 1 (SCA1) is a fatal neurodegenerative genetic disease that is characterized by pronounced neuronal loss and gliosis in the cerebellum. We have previously demonstrated microglial activation, measured as an increase in microglial density in cerebellar cortex and an increase...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Ferro, Austin, Qu, Wenhui, Lukowicz, Abigail, Svedberg, Daniel, Johnson, Andrea, Cvetanovic, Marija
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6033432/
https://ncbi.nlm.nih.gov/pubmed/29975753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0200013
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