Lifespan analysis of brain development, gene expression and behavioral phenotypes in the Ts1Cje, Ts65Dn and Dp(16)1/Yey mouse models of Down syndrome

Down syndrome (DS) results from triplication of human chromosome 21. Neuropathological hallmarks of DS include atypical central nervous system development that manifests prenatally and extends throughout life. As a result, individuals with DS exhibit cognitive and motor deficits, and have delays in...

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Bibliographische Detailangaben
Veröffentlicht in:Dis Model Mech
Hauptverfasser: Aziz, Nadine M., Guedj, Faycal, Pennings, Jeroen L. A., Olmos-Serrano, Jose Luis, Siegel, Ashley, Haydar, Tarik F., Bianchi, Diana W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists Ltd 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6031353/
https://ncbi.nlm.nih.gov/pubmed/29716957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.031013
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