Brain PET Imaging of α7-nAChR with [18F]ASEM: Reproducibility, Occupancy, Receptor Density, and Changes in Schizophrenia

BACKGROUND: The α7 nicotinic acetylcholine receptor increasingly has been implicated in normal brain physiology, as well as in neuropsychiatric disorders. The highly cortical distribution of α7 nicotinic acetylcholine receptor suggests a role in cognition. METHODS: We expanded the first-in-human PET...

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Vydáno v:Int J Neuropsychopharmacol
Hlavní autoři: Wong, Dean F, Kuwabara, Hiroto, Horti, Andrew G, Roberts, Joshua M, Nandi, Ayon, Cascella, Nicola, Brasic, James, Weerts, Elise M, Kitzmiller, Kelly, Phan, Jenny A, Gapasin, Lorena, Sawa, Akira, Valentine, Heather, Wand, Gary, Mishra, Chakradhar, George, Noble, McDonald, Michael, Lesniak, Wojtek, Holt, Daniel P, Azad, Babak B, Dannals, Robert F, Kem, William, Freedman, Robert, Gjedde, Albert
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
Regular Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030963/
https://ncbi.nlm.nih.gov/pubmed/29522184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ijnp/pyy021
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