Brain PET Imaging of α7-nAChR with [18F]ASEM: Reproducibility, Occupancy, Receptor Density, and Changes in Schizophrenia

BACKGROUND: The α7 nicotinic acetylcholine receptor increasingly has been implicated in normal brain physiology, as well as in neuropsychiatric disorders. The highly cortical distribution of α7 nicotinic acetylcholine receptor suggests a role in cognition. METHODS: We expanded the first-in-human PET...

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Veröffentlicht in:Int J Neuropsychopharmacol
Hauptverfasser: Wong, Dean F, Kuwabara, Hiroto, Horti, Andrew G, Roberts, Joshua M, Nandi, Ayon, Cascella, Nicola, Brasic, James, Weerts, Elise M, Kitzmiller, Kelly, Phan, Jenny A, Gapasin, Lorena, Sawa, Akira, Valentine, Heather, Wand, Gary, Mishra, Chakradhar, George, Noble, McDonald, Michael, Lesniak, Wojtek, Holt, Daniel P, Azad, Babak B, Dannals, Robert F, Kem, William, Freedman, Robert, Gjedde, Albert
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
Schlagworte:
Regular Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030963/
https://ncbi.nlm.nih.gov/pubmed/29522184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ijnp/pyy021
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