Brain PET Imaging of α7-nAChR with [18F]ASEM: Reproducibility, Occupancy, Receptor Density, and Changes in Schizophrenia

BACKGROUND: The α7 nicotinic acetylcholine receptor increasingly has been implicated in normal brain physiology, as well as in neuropsychiatric disorders. The highly cortical distribution of α7 nicotinic acetylcholine receptor suggests a role in cognition. METHODS: We expanded the first-in-human PET...

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Dettagli Bibliografici
Pubblicato in:Int J Neuropsychopharmacol
Autori principali: Wong, Dean F, Kuwabara, Hiroto, Horti, Andrew G, Roberts, Joshua M, Nandi, Ayon, Cascella, Nicola, Brasic, James, Weerts, Elise M, Kitzmiller, Kelly, Phan, Jenny A, Gapasin, Lorena, Sawa, Akira, Valentine, Heather, Wand, Gary, Mishra, Chakradhar, George, Noble, McDonald, Michael, Lesniak, Wojtek, Holt, Daniel P, Azad, Babak B, Dannals, Robert F, Kem, William, Freedman, Robert, Gjedde, Albert
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2018
Soggetti:
Regular Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030963/
https://ncbi.nlm.nih.gov/pubmed/29522184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ijnp/pyy021
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