Tripolar chromosome segregation drives the association between maternal genotype at variants spanning PLK4 and aneuploidy in human preimplantation embryos

Aneuploidy is prevalent in human embryos and is the leading cause of pregnancy loss. Many aneuploidies arise during oogenesis, increasing with maternal age. Superimposed on these meiotic aneuploidies are frequent errors occurring during early mitotic divisions, contributing to widespread chromosomal...

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Pubblicato in:Hum Mol Genet
Autori principali: McCoy, Rajiv C, Newnham, Louise J, Ottolini, Christian S, Hoffmann, Eva R, Chatzimeletiou, Katerina, Cornejo, Omar E, Zhan, Qiansheng, Zaninovic, Nikica, Rosenwaks, Zev, Petrov, Dmitri A, Demko, Zachary P, Sigurjonsson, Styrmir, Handyside, Alan H
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2018
Soggetti:
Association Studies Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030883/
https://ncbi.nlm.nih.gov/pubmed/29688390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy147
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