Tripolar chromosome segregation drives the association between maternal genotype at variants spanning PLK4 and aneuploidy in human preimplantation embryos

Aneuploidy is prevalent in human embryos and is the leading cause of pregnancy loss. Many aneuploidies arise during oogenesis, increasing with maternal age. Superimposed on these meiotic aneuploidies are frequent errors occurring during early mitotic divisions, contributing to widespread chromosomal...

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Udgivet i:Hum Mol Genet
Main Authors: McCoy, Rajiv C, Newnham, Louise J, Ottolini, Christian S, Hoffmann, Eva R, Chatzimeletiou, Katerina, Cornejo, Omar E, Zhan, Qiansheng, Zaninovic, Nikica, Rosenwaks, Zev, Petrov, Dmitri A, Demko, Zachary P, Sigurjonsson, Styrmir, Handyside, Alan H
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
Fag:
Association Studies Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030883/
https://ncbi.nlm.nih.gov/pubmed/29688390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy147
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