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Tripolar mitosis and partitioning of the genome arrests human preimplantation development in vitro

Following in vitro fertilisation (IVF), only about half of normally fertilised human embryos develop beyond cleavage and morula stages to form a blastocyst in vitro. Although many human embryos are aneuploid and genomically imbalanced, often as a result of meiotic errors inherited in the oocyte, the...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Ottolini, Christian S., Kitchen, John, Xanthopoulou, Leoni, Gordon, Tony, Summers, Michael C., Handyside, Alan H.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5575028/
https://ncbi.nlm.nih.gov/pubmed/28851957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09693-1
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