Evidence of Selection against Complex Mitotic-Origin Aneuploidy during Preimplantation Development

Whole-chromosome imbalances affect over half of early human embryos and are the leading cause of pregnancy loss. While these errors frequently arise in oocyte meiosis, many such whole-chromosome abnormalities affecting cleavage-stage embryos are the result of chromosome missegregation occurring duri...

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Veröffentlicht in:PLoS Genet
Hauptverfasser: McCoy, Rajiv C., Demko, Zachary P., Ryan, Allison, Banjevic, Milena, Hill, Matthew, Sigurjonsson, Styrmir, Rabinowitz, Matthew, Petrov, Dmitri A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4619652/
https://ncbi.nlm.nih.gov/pubmed/26491874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005601
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