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Common variants spanning PLK4 are associated with mitotic-origin aneuploidy in human embryos

Aneuploidy, the inheritance of an atypical chromosome complement, is common in early human development and is the primary cause of pregnancy loss. By screening day-3 embryos during in vitro fertilization cycles, we identified an association between aneuploidy of putative mitotic origin and linked ge...

詳細記述

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書誌詳細
出版年:Science
主要な著者: McCoy, Rajiv C., Demko, Zachary, Ryan, Allison, Banjevic, Milena, Hill, Matthew, Sigurjonsson, Styrmir, Rabinowitz, Matthew, Fraser, Hunter B., Petrov, Dmitri A.
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5519344/
https://ncbi.nlm.nih.gov/pubmed/25859044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa3337
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