Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumors

As oxygen is essential for many metabolic pathways, tumor hypoxia may impair cancer cell proliferation (1–4). However, the limiting metabolites for proliferation under hypoxia and in tumors are unknown. Here, we assessed proliferation of a collection of cancer cells upon inhibition of the mitochondr...

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Veröffentlicht in:Nat Cell Biol
Hauptverfasser: Garcia-Bermudez, Javier, Baudrier, Lou, La, Konnor, Zhu, Xiphias Ge, Fidelin, Justine, Sviderskiy, Vladislav O, Papagiannakopoulos, Thales, Molina, Henrik, Snuderl, Matija, Lewis, Caroline A., Possemato, Richard L., Birsoy, Kıvanç
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030478/
https://ncbi.nlm.nih.gov/pubmed/29941933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-018-0118-z
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