NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

Environmental nutrient levels impact cancer cell metabolism, resulting in context-dependent gene essentiality(1,2). Here, using loss-of-function screening based on RNA interference, we show that environmental oxygen levels are a major driver of differential essentiality between in vitro model system...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nature
Prif Awduron: Alvarez, Samantha W., Sviderskiy, Vladislav O., Terzi, Erdem M., Papagiannakopoulos, Thales, Moreira, Andre L., Adams, Sylvia, Sabatini, David M., Birsoy, Kıvanç, Possemato, Richard
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808442/
https://ncbi.nlm.nih.gov/pubmed/29168506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature24637
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