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NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis
Environmental nutrient levels impact cancer cell metabolism, resulting in context-dependent gene essentiality(1,2). Here, using loss-of-function screening based on RNA interference, we show that environmental oxygen levels are a major driver of differential essentiality between in vitro model system...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5808442/ https://ncbi.nlm.nih.gov/pubmed/29168506 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature24637 |
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