Cornel Iridoid Glycoside Inhibits Tau Hyperphosphorylation via Regulating Cross-Talk Between GSK-3β and PP2A Signaling

Neurofibrillary pathology contributes to neuronal dysfunction and correlates with the clinical progression of Alzheimer’s disease (AD). Tau phosphorylation is mainly regulated by a balance of glycogen synthase kinase-3β (GSK-3β) and protein phosphatase 2A (PP2A) activities. Cornel iridoid glycoside...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Yang, Cuicui, Li, Xuelian, Gao, Wenbin, Wang, Qi, Zhang, Li, Li, Yali, Li, Lin, Zhang, Lan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6028923/
https://ncbi.nlm.nih.gov/pubmed/29997510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00682
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