Cornel Iridoid Glycoside Attenuates Tau Hyperphosphorylation by Inhibition of PP2A Demethylation

Aim. The aim of the present study was to investigate the effect of cornel iridoid glycoside (CIG) on tau hyperphosphorylation induced by wortmannin (WT) and GF-109203X (GFX) and the underlying mechanisms. Methods. Human neuroblastoma SK-N-SH cells were preincubated with CIG (50, 100, and 200 µg/ml,...

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Main Authors: Yang, Cui-cui, Kuai, Xue-xian, Li, Ya-li, Zhang, Li, Yu, Jian-chun, Li, Lin, Zhang, Lan
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi Publishing Corporation 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3880719/
https://ncbi.nlm.nih.gov/pubmed/24454482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/108486
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