Cornel Iridoid Glycoside Protects Against STAT1-Dependent Synapse and Memory Deficits by Increasing N-Methyl-D-aspartate Receptor Expression in a Tau Transgenic Mice

P301S transgenic mice are an animal model of tauopathy and Alzheimer’s disease (AD), exhibiting tau pathology and synaptic dysfunction. Cornel iridoid glycoside (CIG) is an active ingredient extracted from Cornus officinalis, a traditional Chinese herb. In the present study, the purpose was to inves...

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Vydáno v:Front Aging Neurosci
Hlavní autoři: Ma, Denglei, Huang, Rui, Guo, Kaiwen, Zhao, Zirun, Wei, Weipeng, Gu, Lihong, Li, Lin, Zhang, Lan
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8185567/
https://ncbi.nlm.nih.gov/pubmed/34113246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2021.671206
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