Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis

Centrosome abnormalities are a typical hallmark of human cancers. However, the origin and dynamics of such abnormalities in human cancer are not known. In this study, we examined centrosomes in Barrett’s esophagus tumorigenesis, a well-characterized multistep pathway of progression, from the premali...

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Dettagli Bibliografici
Pubblicato in:J Cell Biol
Autori principali: Lopes, Carla A.M., Mesquita, Marta, Cunha, Ana Isabel, Cardoso, Joana, Carapeta, Sara, Laranjeira, Cátia, Pinto, António E., Pereira-Leal, José B., Dias-Pereira, António, Bettencourt-Dias, Mónica, Chaves, Paula
Natura: Artigo
Lingua:Inglês
Pubblicazione: Rockefeller University Press 2018
Soggetti:
Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6028540/
https://ncbi.nlm.nih.gov/pubmed/29739803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201711191
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