A transgenic mouse model for HLA-B*57:01–linked abacavir drug tolerance and reactivity

Adverse drug reactions (ADRs) are a major obstacle to drug development, and some of these, including hypersensitivity reactions to the HIV reverse transcriptase inhibitor abacavir (ABC), are associated with HLA alleles, particularly HLA-B*57:01. However, not all HLA-B*57:01(+) patients develop ADRs,...

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Udgivet i:J Clin Invest
Main Authors: Cardone, Marco, Garcia, Karla, Tilahun, Mulualem E., Boyd, Lisa F., Gebreyohannes, Sintayehu, Yano, Masahide, Roderiquez, Gregory, Akue, Adovi D., Juengst, Leslie, Mattson, Elliot, Ananthula, Suryatheja, Natarajan, Kannan, Puig, Montserrat, Margulies, David H., Norcross, Michael A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6025983/
https://ncbi.nlm.nih.gov/pubmed/29782330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI99321
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