Abacavir induces loading of novel self-peptides into HLA-B*57:01: an autoimmune model for HLA-associated drug hypersensitivity

BACKGROUND: Abacavir drug hypersensitivity in HIV-treated patients is associated with HLA-B*57:01 expression. To understand the immunochemistry of abacavir drug reactions, we investigated the effects of abacavir on HLA-B*57:01 epitope-binding in vitro and the quality and quantity of self-peptides pr...

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Main Authors: Norcross, Michael A., Luo, Shen, Lu, Li, Boyne, Michael T., Gomarteli, Mary, Rennels, Aaron D., Woodcock, Janet, Margulies, David H., McMurtrey, Curtis, Vernon, Stephen, Hildebrand, William H., Buchli, Rico
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155923/
https://ncbi.nlm.nih.gov/pubmed/22617051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0b013e328355fe8f
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