New Genetic Predictors for Abacavir Tolerance in HLA-B*57:01 Positive Individuals

Abacavir hypersensitivity syndrome (ABC HSS) is strongly associated with carriage of human leukocyte antigen (HLA)-B*57:01, which has a 100% negative predictive value for the development of ABC HSS. However, 45% of individuals who carry HLA-B*57:01 can tolerate ABC. We investigated immune and non-im...

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Publicat a:Hum Immunol
Autors principals: PAVLOS, Rebecca, DESHPANDE, Pooja, CHOPRA, Abha, LEARY, Shay, STRAUTINS, Kaija, NOLAN, David, THORBORN, Daren, SHAEFER, Mark, RAUCH, Andri, DUNN, David, MONTANER, Julio, RACHLIS, Anita, ALMEIDA, Coral-Ann, CHOO, Linda, JAMES, Ian, REDWOOD, Alec J., LI, Yueran, GAUDIERI, Silvana, MALLAL, Simon A., PHILLIPS, Elizabeth J.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7266722/
https://ncbi.nlm.nih.gov/pubmed/32173028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.humimm.2020.02.011
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