Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant

Susceptibility to a clinically significant drug hypersensitivity syndrome associated with abacavir use seems to have a strong genetic component. We have previously shown that the presence of HLA-B*5701 strongly predicts abacavir hypersensitivity and have identified a potential susceptibility locus w...

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Bibliografiske detaljer
Main Authors: Martin, Annalise M., Nolan, David, Gaudieri, Silvana, Almeida, Coral Ann, Nolan, Richard, James, Ian, Carvalho, Filipa, Phillips, Elizabeth, Christiansen, Frank T., Purcell, Anthony W., McCluskey, James, Mallal, Simon
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC384715/
https://ncbi.nlm.nih.gov/pubmed/15024131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307067101
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