Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant

Susceptibility to a clinically significant drug hypersensitivity syndrome associated with abacavir use seems to have a strong genetic component. We have previously shown that the presence of HLA-B*5701 strongly predicts abacavir hypersensitivity and have identified a potential susceptibility locus w...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Martin, Annalise M., Nolan, David, Gaudieri, Silvana, Almeida, Coral Ann, Nolan, Richard, James, Ian, Carvalho, Filipa, Phillips, Elizabeth, Christiansen, Frank T., Purcell, Anthony W., McCluskey, James, Mallal, Simon
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC384715/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15024131/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0307067101
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