Identifying Patient-Specific Epstein-Barr Nuclear Antigen-1 Genetic Variation and Potential Autoreactive Targets Relevant to Multiple Sclerosis Pathogenesis

BACKGROUND: Epstein-Barr virus (EBV) infection represents a major environmental risk factor for multiple sclerosis (MS), with evidence of selective expansion of Epstein-Barr Nuclear Antigen-1 (EBNA1)-specific CD4+ T cells that cross-recognize MS-associated myelin antigens in MS patients. HLA-DRB1*15...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Tschochner, Monika, Leary, Shay, Cooper, Don, Strautins, Kaija, Chopra, Abha, Clark, Hayley, Choo, Linda, Dunn, David, James, Ian, Carroll, William M., Kermode, Allan G., Nolan, David
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4744032/
https://ncbi.nlm.nih.gov/pubmed/26849221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0147567
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