A transgenic mouse model for HLA-B*57:01–linked abacavir drug tolerance and reactivity

Adverse drug reactions (ADRs) are a major obstacle to drug development, and some of these, including hypersensitivity reactions to the HIV reverse transcriptase inhibitor abacavir (ABC), are associated with HLA alleles, particularly HLA-B*57:01. However, not all HLA-B*57:01(+) patients develop ADRs,...

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Библиографические подробности
Опубликовано в: :J Clin Invest
Главные авторы: Cardone, Marco, Garcia, Karla, Tilahun, Mulualem E., Boyd, Lisa F., Gebreyohannes, Sintayehu, Yano, Masahide, Roderiquez, Gregory, Akue, Adovi D., Juengst, Leslie, Mattson, Elliot, Ananthula, Suryatheja, Natarajan, Kannan, Puig, Montserrat, Margulies, David H., Norcross, Michael A.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2018
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6025983/
https://ncbi.nlm.nih.gov/pubmed/29782330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI99321
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