A transgenic mouse model for HLA-B*57:01–linked abacavir drug tolerance and reactivity

Adverse drug reactions (ADRs) are a major obstacle to drug development, and some of these, including hypersensitivity reactions to the HIV reverse transcriptase inhibitor abacavir (ABC), are associated with HLA alleles, particularly HLA-B*57:01. However, not all HLA-B*57:01(+) patients develop ADRs,...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Cardone, Marco, Garcia, Karla, Tilahun, Mulualem E., Boyd, Lisa F., Gebreyohannes, Sintayehu, Yano, Masahide, Roderiquez, Gregory, Akue, Adovi D., Juengst, Leslie, Mattson, Elliot, Ananthula, Suryatheja, Natarajan, Kannan, Puig, Montserrat, Margulies, David H., Norcross, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6025983/
https://ncbi.nlm.nih.gov/pubmed/29782330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI99321
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