Alterations in the HLA-B*57:01 Immunopeptidome by Flucloxacillin and Immunogenicity of Drug-Haptenated Peptides

Neoantigen formation due to the interaction of drug molecules with human leukocyte antigen (HLA)-peptide complexes can lead to severe hypersensitivity reactions. Flucloxacillin (FLX), a β-lactam antibiotic for narrow-spectrum gram-positive bacterial infections, has been associated with severe immune...

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Detalles Bibliográficos
Publicado en:Front Immunol
Main Authors: Puig, Montserrat, Ananthula, Suryatheja, Venna, Ramesh, Kumar Polumuri, Swamy, Mattson, Elliot, Walker, Lacey M., Cardone, Marco, Takahashi, Mayumi, Su, Shan, Boyd, Lisa F., Natarajan, Kannan, Abdoulaeva, Galina, Wu, Wells W., Roderiquez, Gregory, Hildebrand, William H., Beaucage, Serge L., Li, Zhihua, Margulies, David H., Norcross, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7900192/
https://ncbi.nlm.nih.gov/pubmed/33633747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.629399
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