Alterations in the HLA-B*57:01 Immunopeptidome by Flucloxacillin and Immunogenicity of Drug-Haptenated Peptides

Neoantigen formation due to the interaction of drug molecules with human leukocyte antigen (HLA)-peptide complexes can lead to severe hypersensitivity reactions. Flucloxacillin (FLX), a β-lactam antibiotic for narrow-spectrum gram-positive bacterial infections, has been associated with severe immune...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Puig, Montserrat, Ananthula, Suryatheja, Venna, Ramesh, Kumar Polumuri, Swamy, Mattson, Elliot, Walker, Lacey M., Cardone, Marco, Takahashi, Mayumi, Su, Shan, Boyd, Lisa F., Natarajan, Kannan, Abdoulaeva, Galina, Wu, Wells W., Roderiquez, Gregory, Hildebrand, William H., Beaucage, Serge L., Li, Zhihua, Margulies, David H., Norcross, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7900192/
https://ncbi.nlm.nih.gov/pubmed/33633747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.629399
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