Alterations in the HLA-B*57:01 Immunopeptidome by Flucloxacillin and Immunogenicity of Drug-Haptenated Peptides

Neoantigen formation due to the interaction of drug molecules with human leukocyte antigen (HLA)-peptide complexes can lead to severe hypersensitivity reactions. Flucloxacillin (FLX), a β-lactam antibiotic for narrow-spectrum gram-positive bacterial infections, has been associated with severe immune...

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Pubblicato in:Front Immunol
Autori principali: Puig, Montserrat, Ananthula, Suryatheja, Venna, Ramesh, Kumar Polumuri, Swamy, Mattson, Elliot, Walker, Lacey M., Cardone, Marco, Takahashi, Mayumi, Su, Shan, Boyd, Lisa F., Natarajan, Kannan, Abdoulaeva, Galina, Wu, Wells W., Roderiquez, Gregory, Hildebrand, William H., Beaucage, Serge L., Li, Zhihua, Margulies, David H., Norcross, Michael A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7900192/
https://ncbi.nlm.nih.gov/pubmed/33633747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.629399
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