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Parkin regulates NF-κB by mediating site-specific ubiquitination of RIPK1

Parkin (Park2), a RING-between-RING-type E3 ubiquitin ligase, has been implicated in regulating NF-κB. Mutations in Parkin are associated with Parkinson’s disease. Here we investigated the interaction of Parkin with Receptor-interacting protein kinase 1 (RIPK1) kinase, a key mediator of multiple sig...

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Vydáno v:Cell Death Dis
Hlavní autoři: Wang, Yu, Shan, Bing, Liang, Yaosi, Wei, Huiting, Yuan, Junying
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6023924/
https://ncbi.nlm.nih.gov/pubmed/29955050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0770-z
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