Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners

RIPK1 is a death-domain (DD) containing kinase involved in regulating apoptosis, necroptosis and inflammation. RIPK1 activation is known to be regulated by its DD-mediated interaction and ubiquitination, though underlying mechanisms remain incompletely understood. Here we show that K627 in human RIP...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Li, Xingyan, Zhang, Mengmeng, Huang, Xinyue, Liang, Wei, Li, Ganquan, Lu, Xiaojuan, Li, Yanxia, Pan, Heling, Shi, Linyu, Zhu, Hong, Qian, Lihui, Shan, Bing, Yuan, Junying
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7733462/
https://ncbi.nlm.nih.gov/pubmed/33311474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19935-y
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