USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1

The ubiquitin–proteasome system (UPS) and autophagy are two major intracellular degradative mechanisms that mediate the turnover of complementary repertoires of intracellular proteomes. Simultaneously activating both UPS and autophagy might provide a powerful strategy for the clearance of misfolded...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Xu, Daichao, Shan, Bing, Sun, Huawang, Xiao, Juan, Zhu, Kezhou, Xie, Xingxing, Li, Xingyan, Liang, Wei, Lu, Xiaojuan, Qian, Lihui, Yuan, Junying
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5002977/
https://ncbi.nlm.nih.gov/pubmed/27542828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.285122.116
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