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Traf6 and A20 Regulate Lysine 63-Linked Ubiquitination of Beclin 1 Controlling TLR4-Induced Autophagy
Autophagy delivers cytoplasmic constituents to autolysosomes and has been linked to both innate and adaptive immunity. Toll-Like Receptor 4 (TLR4) signaling induces autophagy and recruits Beclin 1 to the receptor complex. Here we show that Traf6-mediated lysine (K) 63-linked ubiquitination of Beclin...
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| Publicado no: | Sci Signal |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6335036/ https://ncbi.nlm.nih.gov/pubmed/20501938 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2000751 |
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